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N⁴-Hydroxycytidine triphosphate– CAS 34973-27-8

Characterisation

CAS: 34973-27-8, 2678486-13-8 (Li⁺ salt), 1955521-97-7 ( Et₃NH⁺ salt)

IUPAC Name: Uridine 5′-(tetrahydrogen triphosphate), 4-oxime (8CI, 9CI, ACI)

Other names: EIDD 2061, EIDD-1931 triphosphate, N⁴-Hydroxy-CTP, N⁴-Hydroxycytidine triphosphate, NHCTP

Molecular formula: C₁₃H₁₉N₃O₇

Description

N⁴-Hydroxycytidine triphosphate– CAS 34973-27-8 is responsible for antiviral activity. The 5′-O-triphosphate (β-_D–N⁴-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.

You can read more about Molnupiravir in our article.

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