3′,4′-Didehydro-3′-deoxyadenosine diphosphate– CAS 2761971-64-4
Characterisation
CAS: 2761971-64-4
IUPAC Name: ((4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-4,5-dihydrofuran-2-yl)methyl trihydrogen diphosphate
Other names: DdhA-DP, Ddh-A-DP, 3′,4′-Didehydro-3′-deoxyadenosine diphosphate, DdhA diphosphate
Molecular weight: 409.19 g/mol
Molecular formula: C10
InChI: InChI=1S/C10H13N5O9P2/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(23-10)2-22-26(20,21)24-25(17,18)19/h1,3-4,6,10,16H,2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/t6-,10+/m0/s1
Description
3′,4′-Didehydro-3′-deoxyadenosine diphosphate is a metabolite of is 3′,4′-Didehydro-3′-deoxyadenosine (DdhA). A related compound, 3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.
References
- WO2022038539 A2 2022-02-24
- https://doi.org/10.1021/ja0013780
- https://doi.org/10.1016/j.tetlet.2010.10.117
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