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Adefovir diphosphate – CAS 129532-77-0

Characterisation

CAS: 129532-77-0, 255835-57-5 (Li⁺ salt), 1346598-45-5 (Et₃NH⁺ salt)

IUPAC Name: 2-(6-aminopurin-9-yl)ethoxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxyphosphinic acid

Other names: PMEApp, Adefovir diphosphate, PMEA-DP,

Molecular weight: 433.15 g/mol

Molecular formula: C₈H₁₄N₅O₁₀P₃

InChI: InChI=1S/C8H14N5O10P3/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-21-5-24(14,15)22-26(19,20)23-25(16,17)18/h3-4H,1-2,5H2,(H,14,15)(H,19,20)(H2,9,10,11)(H2,16,17,18)

Description

Adefovir diphosphate is a metabolite of adefovir. An antiviral acyclic nucleoside phosphonate (ANP) analog known as adefovir monophosphate has activity against the herpes, hepatitis B, and human immunodeficiency viruses (HIV). For the treatment of hepatitis B, it is an oral acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that inhibits reverse transcriptase.

References

• https://doi.org/10.1073/pnas.0306552101
• https://doi.org/10.1128/AAC.39.8.1888
• https://doi.org/10.1016/S0006-2952(99)00118-5

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