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3′,4′-Didehydro-3′-deoxycytidine triphosphate

Characterisation

CAS: 2279171-34-3, 2657712-17-7 ( Et₃NH⁺ salt)

IUPAC Name: 2(1H)-Pyrimidinone, 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-4-Amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]-1,2-dihydropyrimidin-2-one triphosphate

Other names: 4-amino-1-[(2R,3R)-2,3-dihydro-3-hydroxy-5-(hydroxymethyl)-2-furanyl]-2(1H)-Pyrimidinone Triphosphate, DdhCTP, DdhC-TP

Molecular weight: 465.15 g/mol

Molecular formula: C₉H₁₄N₃O₁₃P₃

InChI: InChI=1S/C10H12N2O4/c1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8/h2,4,8,13H,3,5H2,1H3,(H,11,14,15)/t8-/m1/s1

Description

3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have an antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

3′,4′-didehydro-3′-deoxycytidine triphosphate is provided as triethylammonium salt.

References

• https://doi.org/10.1021/jp072014y
• https://doi.org/10.1038/nbt1001-940
• https://doi.org/10.1016/j.medj.2022.01.009
• https://doi.org/10.1021/jo00001a011
• https://doi.org/10.1039/C39930000149

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