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Adefovir monophosphate – CAS 129556-87-2

Characterisation

CAS: 129556-87-2

IUPAC Name: 2-(6-aminopurin-9-yl)ethoxymethyl-phosphonooxyphosphinic acid

Other names: 46TMW03MNX, Adefovir phosphate

Molecular weight: 353.17 g/mol

Molecular formula: C₈H₁₃N₅O₇P₂

InChI: InChI=1S/C8H13N5O7P2/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-19-5-21(14,15)20-22(16,17)18/h3-4H,1-2,5H2,(H,14,15)(H2,9,10,11)(H2,16,17,18)

Description

Adefovir monophosphate is a metabolite of adefovir. An antiviral acyclic nucleoside phosphonate (ANP) analog known as adefovir monophosphate has activity against the herpes, hepatitis B, and human immunodeficiency viruses (HIV). For the treatment of hepatitis B, it is an oral acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that inhibits reverse transcriptase.

References

• https://doi.org/10.1002/hep.510280629
• https://doi.org/10.1016/j.bcp.2004.07.010
• https://doi.org/10.1128/AAC.39.10.2304

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