Alaptide CAS 90058-29-0

Alaptide – CAS 90058-29-0

Alaptide is synthesised by Santiago Lab (Prague, Czech Republic).

We are having ≥ 500 g of Alaptide in stock. If you are interested, request a quote.

Purity (LC-MS)

95%+ | Certificate of Analysis

Package contents

Alaptide

This compound is for research use only. We do not sell to patients or for veterinary use.

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Description
Additional information

Alaptide

Characterisation

CAS: 90058-29-0

IUPAC Name: (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione

Other names: Alaptide, VUFB-15754, Cyclo(alanine-(1-amino-1-cyclopentane)carbonyl)

Molecular weight: 182.22 g/mol

Molecular formula: C₉H₁₄N₂O₂

Description

Alaptide is synthesised by Santiago Lab (Prague, Czech Republic). We are having ≥ 500 g of Alaptide in stock. If you are interested in this product, contact us.

The molecule is composed of two amino acids, L-alanine and cycloleucine, that are interlocked into a spirocycle.

Alaptide enables a significant stimulating effect of human diploid cells (LEP-19) without transformation changes in their morphology. This effect can be used in various areas of regenerative medicine, such as treating burn injuries, skin treatment etc.

Epidermal regeneration abilities were also proved on a number of tests using domestic pigs. It was found out that Alaptide causes a faster skin regeneration of various injuries.

Moreover, Alaptide is also used as a modifier of permeation through the stratum corneum (SC), the least permeable layer of skin. Even though it is almost insoluble in water (0.1104 g/100 mL), they are physical ways (such as milling with various emulsifiers and stabilisers) how to increase its solubility and, therefore, the ability of permeation.

Interestingly, it was originally developed and tested for its nootropic effects with possible oral administration.

You can read more in our article.

Chemicals are distributed worldwide

Buy Alaptide now, get your order in 48 hours

Shipping through DHL in 48 hours. We can also arrange shipping on dry ice.
All compounds are safely and rigorously packed
Delivery time 24 hours in Europe, 24-48 hours to USA, Canada, Asia
Shipping worldwide for free.

Payment

We are sending the invoice the same day as the shipment
We can modify the invoice for the academic institution so that the order can be paid from grants
Payment terms 30 days net

References	References CS Pat. 276270, 1992 CS Pat. 308845, 2021 Kasafirek et. al., Synthesis and Antiproliferative Activity of Spirocyclic Cyclodipeptides, Derivatives of 1-Amino-1-cyclobutanecarboxylic Acid, Collect. Czech. Chem. Commun. 1993, 58, 2987-2993. doi.org/10.1135/cccc19932987 Jampílek J., Dohnal J. (2015) Alaptide as Transdermal Permeation Modifier. In: Dragicevic N., Maibach H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_8 Nikifor Asatiani, Vít Novotný, David Lukáš, Petr Mikeš, A novel approach to studying the kinetics of release of Alaptide from Poly-ε-caprolactone nanofibers, Drug Deliv Sci Technol. 2021, 63, 102492. https://doi.org/10.1016/j.jddst.2021.102492.

References

CS Pat. 276270, 1992

CS Pat. 308845, 2021

Kasafirek et. al., Synthesis and Antiproliferative Activity of Spirocyclic Cyclodipeptides, Derivatives of 1-Amino-1-cyclobutanecarboxylic Acid, Collect. Czech. Chem. Commun. 1993, 58, 2987-2993. doi.org/10.1135/cccc19932987

Jampílek J., Dohnal J. (2015) Alaptide as Transdermal Permeation Modifier. In: Dragicevic N., Maibach H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_8

Nikifor Asatiani, Vít Novotný, David Lukáš, Petr Mikeš, A novel approach to studying the kinetics of release of Alaptide from Poly-ε-caprolactone nanofibers, Drug Deliv Sci Technol. 2021, 63, 102492. https://doi.org/10.1016/j.jddst.2021.102492.