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Molnupiravir

Characterisation

CAS: 2349386-89-4

IUPAC Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl 2-methylpropanoate

Other names: EIDD 2801, Uridine-5′-methylpropanoate-4-oxime, Lagevrio, MK-4482, prodrug-EIDD-1931

Molecular weight: 329.31 g/mol

Molecular formula: C₁₃H₁₉N₃O₇

Description

Molnupiravir is used as a prodrug. It breaks down into a free ribonucleoside derivative inside the cell, and kinases convert the nucleoside into its relative 5‘-O-triphosphate, responsible for antiviral activity. The 5′-O-triphosphate (β-_D–N⁴-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.

You can read more about Molnupiravir in our article.

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